Animal Care and Use Committee, or IACUC, is a committee
appointed by the Chief Executive Officer of the
institution. The IACUC has certain federally mandated
responsibilities, such as review of protocols and
periodic evaluations of the program of animal care and
use, including inspections of facilities. The IACUC
Guidebook (PDF - 1.2 MB) , published in 1992 by OPRR and
the Applied Research Ethics National Association
(ARENA), is a recommended manual for IACUCs.
This committee is
by required to Institutions that use live animals in
their research facilities using federal and NIH funds :
(Office of Laboratory Animal Welfare), reflects
the August 7, 2002 PHS Policy amendment permitting
institutions with PHS Animal Welfare Assurances to
submit verification of Institutional Animal Care and
Use Committee (IACUC) approval for competing
applications or proposals subsequent to peer review
but prior to award (67 FR 51289). Also included in
this reprint are the U.S. Government Principles for
the Utilization and Care of Vertebrate Animals Used
in Testing, Research and Training. The U.S.
Principles were promulgated in 1985 by the
Interagency Research Animal Committee and adopted by
U.S. Government agencies that either develop
requirements for or sponsor procedures involving the
use of vertebrate animals. The Principles were
incorporated into the PHS Policy in 1986 and
continue to provide a framework for conducting
research in accordance with the Policy.
USDA/Animal and Plant Health Inspection Service /
Department of Agriculture / Animal Welfare
Regulations - The Chief Executive Officer of the
research facility shall appoint an Institutional
Animal Care and Use Committee (IACUC), qualified
through the experience and expertise of its members
to assess the research facility's animal program,
facilities, and procedures. Except as specifically
authorized by law or these regulations, nothing in
this part shall be deemed to permit the Committee or
IACUC to prescribe methods or set standards for the
design, performance, or conduct of actual research
or experimentation by a research facility.
Procedures with animals will avoid or minimize
discomfort, distress, and pain to the
animals, consistent with sound research design.
Procedures that may cause more than momentary or
slight pain or distress to the
animals will be performed with appropriate sedation,
analgesia, or anesthesia, unless the procedure is
justified for scientific reasons in writing by the
that would otherwise experience severe or chronic
pain or distress that cannot be relieved will be
painlessly killed at the end of the procedure or, if
appropriate, during the procedure.
living conditions of animals will be appropriate for
their species and contribute to their health and
comfort. The housing, feeding, and nonmedical care
of the animals will be directed by a veterinarian or
other scientist trained and experienced in the
proper care, handling, and use of the species being
maintained or studied.
care for animals will be available and provided as
necessary by a qualified veterinarian.
conducting procedures on the species being
maintained or studied will be appropriately
qualified and trained in those procedures.
of euthanasia used will be consistent with the
recommendations of the American Veterinary Medical
Association (AVMA) Panel on Euthanasia, unless a
deviation is justified for scientific reasons in
writing by the investigator.
(from IV. C.1.a.-g. of the PHS Policy)