Recruitment sites include the Ponce School of Medicine
Outpatient Clinic, Auxilio Mutuo Hospital (San Juan), Damas
Hospital (Ponce), St. Lukes Hospital (Ponce) and Tito Mattei
Hospital (Yauco). Participants (cases and controls) are all
of Hispanic origin since this represents the majority of the
population of Puerto Rico. Controls are women without breast
cancer. Cases and controls are compared regarding their DNA
repair capacities (DRC) in peripheral blood lymphocytes.
- Women have to be 21 years or older.
- Only cases with primary and
metastatic breast carcinoma tumors, rather than
secondary to other type of cancer are recruited.
- Pathology report from each patient is
obtained to know the tumor grade, tumor size, presence
of axillaries’ lymph node metastasis, and other
clinically relevant information.
- Fill an epidemiological questionnaire
soliciting information and variables that are related to
breast carcinoma risk is provided to each participant.
Selection of cases and controls
- Incident cases are recruited
consecutively from all the participating clinical
practices throughout Puerto Rico (convenience sample of
newly diagnosed BC patients residing in the Island).
- Controls are recruited consecutively
from individuals visiting gynecological and primary care
medical offices in Puerto Rico for their routine
mammography and other types of screening.
- DNA repair capacity (DRC) data is
analyzed including controls with and without familial
history of breast carcinoma. There is the possibility
that controls will have more weight than cancer cases,
that potential confounding factor as well as any other
confounding factors that became apparent were carefully
analyzed and properly adjusted for.. These selection
procedures minimized selection bias due to differences
in mode of recruiting cases and controls.
The three main criteria for selecting all controls are
that all participants within the last six months prior
- Had been examined by their
primary physicians (normal clinical breast
examination) and have received a normal mammogram
within the last six months.
- Controls consist of women
recruited from the same population (clinics,
physician offices and hospitals) where the cases
came from, and in the eventuality that they
developed breast carcinoma; they would be treated in
the same clinics where the cases were recruited.
|***Women that have
received chemotherapy, radiotherapy, and blood transfusions
within the last five years, or have any genetic or acquired
immunodeficiencies, unfortunately can not participate in the
- If you will like to participate
Hannia E. Delgado
U-56 Program Coordinator and
MBRS Breast Cancer Project
Ponce School of Medicine
Dept. of Pharmacology and Toxicology
Dr. Matta's Laboratory
Phone:(787)-840-2575 ext 2197
P.O. Box 7004
Ponce, Puerto Rico 00732-7004