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Caroline B. Appleyard, PhD

Department of Physiology and Pharmacology

Recent Publications


Pagán, B., Isidro, A.A., Coppola, D., Chen, Z., Ren, Y., Wu, J., Appleyard, C.B. (2010) Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer. Anticancer Res., in press.

Uronis JM, Arthur JC, Keku T, Fodor A, Carroll IM, Cruz ML, Appleyard CB, Jobin C (2010) Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS induced colitis Inflammatory Bowel Diseases Jun 17 [Epub ahead of print].

Appleyard CB, Morales M and Santiago C (2008) Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon Digestive Diseases and Sciences Jan;53(1):220-8.  

Santiago OI, Rivera E, Ferder L and Appleyard CB (2008). An angiotensin II receptor antagonist reduces inflammatory parameters in two models of colitis. Regulatory Peptides 146;250-259.

Cuevas M, Thompson KJ, Flores I, Santiago OI and Appleyard CB (2008) El estrés incontrolable afecta la progresión de la endometriosis Revista Puertorriqueña de Medicina y Salud Pública XI (II) 20-26.

Santiago C, Pagán B, Isidro AA and Appleyard CB (2007) Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer Cancer Research Nov 15;67(22):10766-73. Cover illustration.

Appleyard CB, Cruz ML, Rivera E, Hernandez GA and Flores I (2007) Experimental endometriosis in the rat is correlated with colonic motor function alterations but not with bacterial load Reproductive Sciences Dec;14(8):815-24.

Flores I, Rivera E, Ruiz LA, Santiago OI, Vernon MW and Appleyard CB (2007) Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease Fertility and Sterility 87(5):1180-99. Cover illustration.

Rivera E, Flores I, Rivera E, and Appleyard CB (2006). Molecular profiling of a rat model of colitis: Validation of known inflammatory genes and identification of novel disease-associated targets Inflammatory Bowel Diseases Oct;12(10):950-966.

Appleyard C B, Morales M and Percy W H (2006) Regional Variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon Digestive Diseases and Sciences Mar;51(3):506-16.

Rojas-Cartagena C, Flores I and Appleyard C B (2005) Role of Tumor Necrosis Factor Receptors in an Animal Model of acute Colitis Cytokine Oct 21;32(2):85-93.

Rojas-Cartagena C, Appleyard C B, Santiago O I and Flores I (2005) Experimental intestinal endometriosis is characterized by increased levels of soluble TNFRSF1B and down regulation of Tnfrsf1a and Tnfrsf1b gene expression Biology of Reproduction Dec 73(6):1211-8.

Hernández G A, Valentín M R and Appleyard C B (2005) Effect of bacterial peptides on intestinal inflammation in animal models of acute and chronic “relapsed” colitis Digestive Diseases and Sciences 50(8):1444-1453.