|We study the
GABA receptor type A (GABAAR), a member of the ligand-gated ion
channel (LGIC) superfamily whose members include most
neurotransmitter receptors. GABAA receptors regulate the
majority of fast inhibition in the mammalian brain, and are the
target for multiple drug types, including sleep aids,
anti-anxiety medication, anesthetics, alcohol and neurosteroids.
We combine molecular biology, biochemistry and electrophysiology
to examine GABAAR pharmacology, receptor kinetics, stoichiometry,
GABAergic signaling in the brain during development, and altered
function in disease states such as epilepsy.