| |
| |
Jaime
Matta , PhD |
Chairman
and Professor |
Department
of Pharmacology and Toxicology |
 |
| |
Research
Info |
| |
Research
Interests
|
Dr. Matta research expertise is in the area of toxicology.
Since recruitment at PSM, he have worked in three areas
within that large interdisciplinary field of toxicology.
During the last seven years, he have been primarily focused
in the field of clinical cancer research studying the role
of DNA repair as a risk factor for skin and breast cancer.
The overall goals of his laboratory are to: a) define the role
of DNA repair in skin and breast cancer susceptibility and
resistance to chemotherapeutic agents b) to identify DNA
repair genes that are associated with significant changes in
risk to skin and breast cancer, c) study mechanisms involved
in the regulation of DNA repair gene expression by activated
Stat3 signalling in melanoma skin cancer, d) determine how
genetic and environmental factors influence the risk of skin
and breast cancer at the populational level.
Currently, he particularly interested in the following
questions:
|
- What is the role of DNA repair in the development of skin and breast cancer?
- What are the key DNA repair genes associated with a significant increase or reduction in skin and breast cancer?
- What are the mechanisms involved in the regulation of DNA repair gene expression by activated Stat3 signalling in melanoma skin cancer?
- Are there genes that can be utilized to produce a “molecular signature” that can predict metastasis in melanoma?
|
Research
Presentations |
- Matta J,
Morales L, Cruz, A , Bayona M, Dutil,
J., Gjyshi, A, Monteiro, A and E Suarez.
Expression of DNA repair genes in breast cancer
tumors from Puerto Rican women. Society
of Toxicology (SOT) 52nd Annual Meeting, March
10–14, 2013, Henry Gonzalez Convention Center
San Antonio, Texas. Abstract submitted for
Poster Presentation.
- Matta, J,
Morales, L, Acosta, H, Ortiz, C, Vargas, W,
Echenique, M, Sánchez-Gaetan, F, Ramírez-
Lizardi, E, Torres, A, Ortiz-Rosado, J., Bolaños,
G., González-Cruz, J, Laboy, J, Barnes, R,
Santiago-Medina, S, Romero, A, Martinez, R.,
Suarez, E, Alvarez-Garriga, C and M Bayona.
Molecular epidemiology studies of breast cancer
in Puerto Rico. 13th RCMI
International Symposium on Health Disparities,
Sheraton Hotel, San Juan PR, December 10-13,
2012. Oral Presentation.
- Matta, J,
Guerrero, R, Sidranksy, D, Morales, L, Ortiz, C,
Ostrow, K, Suarez, E, Alvarez-Garriga, C. and M
Bayona. Epigenetic dysregulation of DNA repair
in Puerto Rican women with breast cancer”. 13th
RCMI International Symposium on Health
Disparities, Sheraton Hotel, San Juan PR,
December 10-13, 2012. Poster Presentation.
- Matta, J,
Morales, J, Ortiz, C, Vargas, W, Echenique, M,
Sánchez Gaetan, F, Ramírez Lizardi E,
Torres, A, Ortiz Rosado, J, Bolaños, G, González
Cruz, J, Laboy, J, Barnes, R, Santiago Medina,
S, Romero, A, Martinez, R, Alvarez-Garriga, C
and M Bayona. Triple negative
receptor status is associated with low DNA
repair capacity in women with breast cancer.
2012 CTRC-AACR, San Antonio Breast Cancer
Symposium, December 4-8, 2012. San Antonio, TX.
Abstract accepted for Poster Presentation.
- Matta, J,
Morales, L., Acosta, H., Dutil, J., Monteiro,
A., Alvarez-Garriga C and M. Bayona. The host
cell reactivation (HCR) assay for measuring DNA
repair capacity (DRC) in cancer research after
20 years; re-evaluation and lessons learned.
2012 AACR 103rd. Annual Meeting,
March 31- April 4, 2012, McCormick Place,
Chicago, IL. Poster Presentation.
- Diaz-Zabala
H,
Matta JL,
Dutil J. Genetic ancestry distribution in
basal-cell carcinoma cases and controls from
Puerto Rico, AACR Annual Meeting 2012, Chicago,
Il, March 31 to April 4, 2012.
- Matta, L.,
Alvarez-Garriga C., Morales, L., Vargas, W and
M. Bayona. Smoking is associated with a
diminished DNA repair and increased breast
cancer risk. 2012 SOT 51st Annual Meeting &
ToxExpo, March 11- 15, 2012, Moscone Convention
Center, San Francisco, California. Poster
Presentation.
- Matta, J.
Recent Advances on the Role of DNA Repair in
Breast Cancer. University of Puerto Rico
Comprehensive Cancer Center and U54 Partnership
for Excellence in Cancer Research. October 26,
2011. Oral presentation.
- Dutil J,
Fejerman L, Ziv E, Hunstman S, Arroyo N,
Matta
J, Gonzalez-Bosquet J. The role of
genetic ancestry in breast cancer predisposition
and tumor presentation in Puerto Rican Hispanic.
61th Annual Meeting of the American Society of
Human Genetic/12th International Congress of
Human Genetics, Montreal QC, Canada, October
2011.
- Matta, J.
Recent Advances in Breast Cancer Research in
Puerto Rican Women. AAAS Caribe Division,
Genetics, Environment and Society, October 1,
2011. University of Puerto Rico, Mayaguez,
Invited guest speaker
|
|
|
