DR. KAZIM HUSAIN
Principal Investigator:
Kazim Husain, Ph.D. (Department of Pharmacology and Toxicology)
Education
1977-1979: Bachelor of Sciences (Chemistry, Biology), Lucknow University, India.
1979-1981: Master of Sciences (Biochemistry), Lucknow University, India.
1982-1988: Ph.D. (Chemistry), Faculty of Life Sciences, Kanpur University, India.
1994-1997: Research Associate (Post Doctoral Training), Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
Research Interests and Current Projects
To elucidate the mechanisms of alcohol-induced hypertension and related cardiovascular diseases in a rodent model using pharmacological and genetic tools and to develop preventive strategies such as physical conditioning and antioxidant supplementation.
To study the mechanisms of micro and macro vascular abnormalities in diabetic animal model and to develop novel treatment modalities.
To investigate the role of cigarette smoking and alcohol drinking in the progression and development of UV radiation-induced skin cancer in athymic nude mouse model and to develop therapeutically effective drugs.
To study the role of central and peripheral auditory mechanisms of age-related and platinum drug-induced hearing loss in a rat model and to develop preventive measures.
Current Project: Alcohol-induced hypertension: mechanisms and prevention funded by NIH RCMI.
Laboratory Personnel:
Manuel Vazquez Ortiz
Graduate Student
Modulation of alcohol-induced hypertension
Jainarine Lalla Ortiz-Research Technician
RCMI project
Selected Publications (last three years):
Husain, K. (2002). Exercise conditioning attenuates the hypertensive effects of nitric oxide synthase inhibitor in rat. Molecular and Cellular Biochemistry 231, 129-137.
Husain, K. and Hazelrigg, S. (2002). Oxidative injury due to chronic nitric oxide synthase inhibition in rat: effect of regular exercise on the heart. Biochemica Et Biophysica Acta 1587, 75-82.
Husain, K., Jagannathan, R., Hasan, Z., Trammell, G. L., Rybak, L.P., Hazelrigg, S.R. and Somani, S.M. (2002). Dose response of carboplatin-induced nephrotoxicity in rat. Pharmacology & Toxicology 91, 83-89.
Husain, K., Somani, S.M., Boley, TM. and Hazelrigg, S.R. (2003). Interaction of physical training and chronic nitroglycerin treatment on blood pressure and plasma oxidant/antioxidant systems in rats. Molecular and Cellular Biochemistry 247, 37-44.
Husain K., Whitworth, C., Hazelrigg, S. and Rybak, L. P. (2003). Carboplatin-induced oxidative injury in rat inferior colliculus. International Journal of Toxicology 22, 335-342.
Husain, K. (2003). Interaction of Physical Training and chronic nitroglycerin treatment on blood pressure, nitric oxide and oxidants/antioxidants in the rat heart. Pharmacological Research 48, 253-261.
Husain, K. (2003). Interaction of exercise training and chronic NOS inhibition on blood pressure, heart rate, NO and antioxidants in plasma of rats. Pathophysiology 10, 47-56.
Kelly T C, Whitworth C A, Husain K, Rybak L P. ( 2003).Aminoguanidine reduces cisplatin ototoxicity. Hearing Research 186, 10-16.
Husain, K. (2004). Interaction of regular exercise and chronic nitroglycerin treatment on blood pressure and rat aortic antioxidants.Biochemica Et Biophysica Acta 1688,18-25.
Husain K. Scott, B. Whitworth, C. and Rybak, L.P. (2004).Time response of carboplatin-induced hearing loss in rats. Hearing Research 191, 110-118.
Husain K., Whitworth, C. and Rybak, L.P. (2004). Time response of carboplatin-induced nephrotoxicity in rats. Pharmacological Research 50, 291-300.
Husain K. (2004). Physical conditioning modulates rat cardiac VEGF gene expression in nitric oxide–deficient hypertension. Biochemical Biophysical Research Communication 320, 1169-1174.
Husain K., Whitworth C, Somani S.M.and Rybak L. P. (2004). Partial protection by lipoic acid against carboplatin-induced ototoxicity in rats. Biomedical Environmental Sciences (In Press).
Husain K. Mejia, J. Lalla, J. and Kazim S. (2004). Time response of alcohol-induced alterations in BP, nitric oxide and oxidant to antioxidants balance in the plasma of rats. Experimental Clinical Cardiology (In Press).
Husain K. Mejia, J. Lalla, J. and Kazim S. (2004). Dose response of alcohol-induced changes in BP, nitric oxide and antioxidants in rat plasma. Pharmacological Research (In Press).
