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Eric
Lorenzo Fraticelli, Ph.D. |
Assistant Professor |
Department
of Biochemistry |
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Education |
1988 |
Ph.D. in Molecular Biology , Florida International University, Miami |
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| Current Research, Teaching
and Professional Appointments |
2000
- Present |
Assistant Professor, Biochemistry Department, Ponce School of Medicine, Ponce, PR. |
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| Research
Areas |
Dr. Lorenzo and his staff study the evolution and genomic diversification of the human immunodeficiency virus (HIV). This virus has the ability to change at an amazingly rapid pace its genetic structure through mutation. They have focused on phylogenetic methodologies to reconstruct an evolutionary history of the diverse viral forms and from this to infer epidemiological relationships among cases of suspected infection. Determining the source of infections in cases of unknown epidemiology can help assess the safety of the blood supply, track the spread of disease in novel regions, and help determine the etiology in cases of unusual exposures.
This viral evolution and diversification has also been proposed as essential to disease pathogenesis and progression rate. This rapid diversification for example, allows the virus to rapidly become resistant to drug therapy. Hence, Dr. Lorenzo’s research also focuses in the appearance of viral mutations associated with drug resistance and their relation to rate of disease progression. Recently, Dr. Lorenzo and his staff have been focusing on HIV evolution and diversification before and after highly active antiretroviral therapy (HAART). They are interested on the relationship between viral evolution and diversification, especially viral tropism diversification, and rate of disease progression before and after HAART.
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| Recent
Publications |
2001 |
Lorenzo E, Collins T, Fisher E, and Herrera RJ. New Tat Sequences Support the Hypothesis of Dental Transmission of Human Immunodeficiency Virus-1. Electrophoresis, 2001; Feb, 22(3):438-44.) |
1998 |
Demeter L M, D’Aquila R, Weislow O, Lorenzo E, Erice A, Fitzgibbon J, Shafer R, Richman D, Howard T M, Zhao Y, Fisher E, Hu D, Mayers D, Sylvester S, Arens M, Sannerud K, Rasheed S, Johnson V, Kuritzkes D, Reichelder P and Japour A. Interlaboratory concordance of DNA sequence analysis to detect reverse transcriptase mutations in HIV-1 proviral DNA. ACTG Sequencing Working Group. AIDS Clinical Trials Group. Journal of Virological Methods, 1998; 75(1):93-104 |
1996 |
Unal A, Lorenzo E, Brown M, Smith L, Matsuura S, Scott G, and Scott W. Reverse Transcriptase Mutations in HIV-Infected Children Treated With Zidovudine. Journal of Acquired Immune Deficiency Syndrome and Human Retrovirology 1996; 13: 140-145. |
1996 |
Lorenzo E, Herrera RJ, Fischl MA, Lai S, Hill MD. The Tat and C2-V3 Envelope Genes in the Molecular Epidemiology of the Human Immunodeficiency Virus-1. Virology 1996; 221:210-217.
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| Contact
Information |
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