Education |
1975 |
Shizuoka College of Pharmacy, Japan |
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| Current Research, Teaching
and Professional Appointments |
1991
- Present |
Studying on the regulation of mitogenesis in health and disease, especially focusing on the roles of antioxidants in mitogenic signaling of diverse cell types,
Ponce School of Medicine |
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| Memberships of Professional Societies |
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Regular Membership of American Society for Biochemistry and Molecular Biology |
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Regular membership of American Society for Cell Biology |
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Regular membership of American Society for the Advancement of Science |
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Regular membership of The Society for Free Radical Biology & Medicine |
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| Research
Title and Summary |
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(I) Redox-control of integrin-signaling in health and disease. Integrins are receptors for extracellular matrix (ECM), essential for cell adhesion, migration, proliferation and survival. Disregulation of ECM-integrin binding underlies many diseases including tumorigenesis, metastasis, cardiovascular diseases and kidney diseases. Unlike other receptors, the strength of integrin-ECM binding is under the control of inside-out signaling, and affects diverse cellular responses. Many diseases showing the disregulated ECM-integrin binding are also under oxidative stress with unknown mechanisms. We are working to elucidate the effects of oxidative stress on the integrin-evoked cellular responses. |
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(II) Regulation of mitogenesis in health and disease.
Abnormal mitogenesis plays a major role in the pathogenesis of cancer, atherosclerosis and pulmonary fibosis. Growth factors and hydrogen peroxide (H2O2), a second messenger of mitogenic signaling, cause cell proliferation if not controlled. Catalase, a H2O2 scavenger, acts as a negative regulator of mitogenesis comparable to activators of protein kinase A (PKA). Under normal conditions, cells are capable of restricting their mitogenesis, yet little is known of negative regulators. We are working to elucidate the mechanisms of suppressive effects of antioxidants on the cell mitogenesis.
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| Recent
Publications |
2004 |
Sumio Yano, Nelly Arroyo, Noriko Yano: “Catalase binds GRB2 in tumor cells when stimulated with serum or ligands for integrin receptors.” Free Radical Biology & Medicine, In Press |
2002 |
Sumio Yano & Noriko Yano: “Regulation of catalase enzyme activity by cell signaling molecules.” Molecular and Cellular Biochemistry 240: 119-130 |
| Contact
Information |
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