NAME
Caroline B. Appleyard
TITLE
Associate Professor
Institutions and Locations
United Kingdom
University of Southampton,
United Kingdom
University of Calgary, Canada
University of South Dakota, USA
PhD
Post-Doc.
Post-Doc.
1993
1993-1996
1996-1998
Pharmacology
GI Phys/Pharm.
GI Phys/Pharm.
1993-1996
1996-1998
1998-2001
2001-present
Post-Doctoral Fellow, Gastrointestinal Research Group,
University of Calgary, AB, Canada
Post-Doctoral Fellow, Department of Physiology & Pharmacology, University of South Dakota, SD
Assistant Professor, Department of Physiology,
Ponce School of Medicine, Ponce, PR
Associate Professor, Department of Physiology,
Ponce School of Medicine, Ponce, PR
1997-1998
1997-present
1997-present
1998-present
1999-present
1999-present
1999-present
2000-present
2003-present
2004, 2005
Member, American Physiology Society
Member, American Gastroenterological Association
Member, Gastroenterology Research Group
Chair, Institutional Animal Care and Use Committee at Ponce School of Medicine, Ponce, PR
Ad-hoc Peer Reviewed for Laboratory Investigation (99), Journal of Pharmacology and Experimental Therapeutics (99, 00, 01, 02), American Journal of Physiology (02, 03, 04)
Member, American Association for the Advancement of Science
Member, American Motility Society
Ad-hoc Member, NIGMS/MBRS Review Panel
Member, Abstract Selection Comitte, American Gastroenterological Association
1993-1994
1993
1995
2000
2002, 03, 04
Wellcome Trust Travel Grant
Fellowship from the Canadian Association of Gastroenterology
Young Investigator Award (FASEB Summer Research Conference)
American Motility Society Travel Award
FASEB/MAC Travel Award
Bessos H, Appleyard CB, Micklem LR, and Pepper DS. (1991) Monoclonal antibody leakage from gels: Effect of support, activation, and eluent composition. Preparative Chromatography. 1(3):207-220. Impact Factor: NA
Appleyard CB and Hillier K. (1992) Catabolism of platelet activating factor (PAF) by human colonic mucosa: calcium dependence of the catabolising enzymes. Biochemical Pharmacology. 43(12):2503-2509. Impact Factor: (1992): 2.219.
Appleyard CB and Hillier K. (1995) Biosynthesis of platelet activating factor (PAF) in normal and inflamed human colon mucosa: Evidence for the involvement of the de novo pathway of PAF synthesis in inflammatory bowel disease. Clinical Science. 88(6):713-717. Impact Factor: (1995): 2.070.
Wallace JL, Le T, Carter L, Appleyard CB, and Beck PL. (1995) Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzenesulfonic acid. Journal of Pharmacological and Toxicological Methods. 33(4):237- 239. Impact Factor: (1995): 0.758.
Appleyard CB and Wallace JL. (1995) Reactivation of hapten-induced colitis and its prevention by anti- inflammatory drugs. American Journal of Physiology-Gastrointestinal and Liver Physiology. 269(1 pt 1):G119-125. Impact Factor: NA.
Appleyard CB, McCafferty D-M, Tigley AW, Swain MG, and Wallace JL. (1996) Tumor necrosis factor mediation of NSAID-induced gastric damage: Role ofleukocyte adherence. American Journal of Physiology-Gastrointestinal and Liver Physiology. 270(1):G42-48. Impact Factor: NA.
Davies NM, Roseth AG, Appleyard CB, McKnight W, Del Soldato P, Calignano A, Cirino G, and Wallace JL. (1997) NO-Naproxen vs. Naproxen: Ulcerogenic, analgesic, and anti-inflammatory effects. Alimentary Pharmacology and Therapeutics. 11(1):69-79. Impact Factor: (1997): 3.004.
Ferraz JGP, Tigley AW, Appleyard CB, and Wallace JL. (1997) TNF-a contributes to the pathogenesis of ethanol-induced gastric damage in cirrhotic rats. American Journal of Physiology-Gastrointestinal and Liver Physiology. 272(4 Pt 1):G809-814. Impact Factor: NA.
Swain MG, Appleyard CB, Wallace JL, and Maric M. (1997) TNF-a facilitates inflammation-induced glucocorticoid secretion in rats with biliary obstruction. Journal of Hepatology. 26(2):361-368. Impact Factor (1997): 5.849.
Swain MG, Appleyard CB, Wallace J, Wong H, and Le, T. (1999) Endogenous glucocorticoids released during acute toxic liver injury enhance hepatic IL-10 synthesis and release. American Journal of Physiology-Gastrointestinal and Liver Physiology. 276(1 pt 1):G199-205. Impact Factor (1999): 3.228.
Hathaway CA, Appleyard CB, Percy WH, and Williams JL. (1999) Experimental colitis increases blood-brain barrier permeability in rabbits. American Journal of Physiology-Gastrointestinal and Liver Physiology. 276(5 pt 1): G1174-1180. Impact Factor (1999): 3.228.
Appleyard CB, Williams JL, Hathaway CA, and Percy WH. (1999) Temporal patterns of colonic blood flow and tissue damage in an animal model of colitis. Digestive Diseases and Sciences 44:413-438. Impact Factor (2003): 2.183.
Asfaha S, MacNaughton WK, Appleyard CB, Chadee K, and Wallace JL. (2001) Persistent epithelial dysfunction and bacterial translocation after resolution of colitis in the rat. American Journal of Physiology-Gastrointestinal and Liver Physiology-Gastrointestinal and Liver Physiology. 281(3):G635-644. Impact Factor (2001): 3.660.
Appleyard CB, Alvarez A, and Percy WH. (2002) Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis. Digestive Diseases and Sciences. 47(9):2007-2014. Impact Factor (2002): 1.438.
Hernández GA and Appleyard CB. (2003) Bacterial load in animal models of acute and chronic "reactivated" colitis. Digestion. 67(3):161-169. Impact Factor (2003): 1.399.
Appleyard CB, Hernández GA, and Ríos-Bedoya CF. (2004) Basic epidemiology of inflammatory bowel disease in Puerto Rico. Inflammatory Bowel Diseases. 10(2):106-111. Impact Factor (2003): 3.023.
Hernández GA, Valentín MR, and Appleyard CB. Effect of bacterial peptides on intestinal inflammation in animal models of acute and chronic “relapsed” colitis. Digestive Diseases. In Press. Impact Factor (2003): 1.387.
Rojas-Cartagena C, Flores I, and Appleyard CB. Role of tumor necrosis factor receptors in an animal model of acute colitis. Cytokine. In Press. Impact Factor (2003): 2.183.
Hernández GA and Appleyard CB. (2003) The effect of formyl-methionyl-leucyl-phenylalanine (FMLP) on intestinal inflammation in models of acute and relapsed phase of colitis. Gastroenterology. 126, no. 4, Suppl. LA480.
Rojas C, Appleyard CB, Santiago OI, Santiago C, Resto K, and Flores I. (2003) TRAF 1 overexpression in an animal model of intestinal endometriosis. Biology of Reproduction. 68 (supplement I): A400.
Appleyard CB, Morales M, Cuevas M, and Santiago C. (2004) Phosphodiesterase inhibition can ameliorate chronic intestinal inflammation. FASEB Journal. 18, no. 5, A1265.
Involvement of TNF in Intestinal Inflammation in a Reactivated Model of Colitis.
Major goals: To measure the levels of TNF alpha following colitis induction and correlate with intestinal inflammation and secretion. Investigate the effects of inhibition of TNF alpha on the above parameters.
Role: PI
NIH-NIGMS-MBRS S06 GM 08239 Flores (PI; Torres PD) 06/01/02-05/31/05
Differentiation of TNF pathways in Intestinal Endometriosis and Crohn's Disease
Major goals: The long term goal of this project is to develop a non-invasive diagnostic test that will differentiate between intestinal endometriosis and inflammatory bowel disease. The differential activation of TNF receptors and the associated signaling molecules in acute inflammation will be determined.
Role: Co-Investigator
NIH-NCRR/RCMI 2G12 RR03050 Appleyard (PI; Yamamura PD) 09/30/03 - 06/30/08
Role of Bacterial Peptides in Chronic Intestinal Inflammation
Major goals: To determine whether the bacterial peptide fMLP can exacerbate intestinal inflammation in the acute and chronic phase of colitis by altering the secretory and motility responses of the intestine. Levels of inflammatory and proinflammatory cytokines will be measured.
Role: PI
Nutritional Regulation of Catalase and Colorectal Cancer
The overall goal of this project is to understand the mechanisms of butyrate-dependent catalase regulation with a view to developing new strategies to control colon cancer.
Role: Co-Investigator
