NAME

Jaime L. Matta

TITLE

Professor and Chairman

Member Editorial Board Biological Trace Element Research

(Total: 17 papers, 31 abstracts)

Matta JL, Ramos JM, Armstrong RA, D’Antoni H. Environmental UV-A and UV-B Threshold Doses for Apoptosis and Necrosis in Human Fibroblasts. Photochem Photobiol. In Press.

Ramos JM, Villa JL, Ruiz-Rivera A, Matta JL.UV dose determines key characteristics of nonmelanoma skin cancer . Cancer Epidemiol Biomarkers Prev . Dec 2004;13(12):2006-2011 .

Ramos JM, Ruiz-Rivera A, Colen R, López ID, Grossman L, Matta JL.DNA repair and breast carcinoma susceptibility in women. Cancer. Apr 2004;100(7):1352-1357.

Matta JL, Villa JL, Ramos JM, Sánchez J, Chompré G, Ruiz-Rivera A, Grossman L. DNA repair and nonmelanoma skin cancer in Puerto Rican populations. J Am Acad Dermatol. Sep 2003;49(3):433-439.

Gonzalez MJ, Mora EM, Miranda- Massari JR, Matta JL, Riordan HD, Riordan NH. Inhibition of human breast carcinoma cell proliferation by ascorbate and copper. PR Health Sci J. Mar 2002;21(1):21-23 .

Matta JL, Navas J, Milad MR, Manger RL, Hupka A, Frazer de Llado TE. 2002. A pilot study for the detection of acute ciguatera intoxication in human blood. J Toxicol Clin-Toxic. Apr 2002;40(1):49-57.

Rojas-Cartagena C, Matos B, Santiago N, Reymunde A, Matta JL.Hepatitis C patients in Puerto Rico have an altered iron balance. Biol Trac Elem Res. Dec 2001;84(1-3):239-245.

Matta JL, Milad MR, Manger RL, Tosteson TR. Heavy metals, lipid peroxidation, and ciguatera toxicity in the liver of the Caribbean barracuda ( Sphyraena barracuda). Biol Trac Elem Res. Oct 1999;70:69-79.

Matta JL, Nazario CM, Armstrong RA, Navas J. Epidemiological trends in skin cancer melanoma in Puerto Rico from 1975-1991. Bol Asoc Med PR. Jan-Mar 1998;90(1-3):8-11.

Matta JL and Chapman DJ. 1995. Effects of light, temperature and desiccation on the net emersed productivity of the intertidal macroalga Colpomenia peregrina Sauv. (Hamel ). J Exp Mar Biol Ecol. Jun 1995;189(1):13-27.

Matta JL and Tosteson TR. 1995. Preliminary studies on the role of oxygen-derived free radicals and lipid peroxidation in ciguatera poisoning. International Symposium on Ciguatera and Marine Natural Products held in South Kohala, Hawaii, August 8-10, 1994, pp. 109-120.

Matta JL and Tosteson TR. 1994. Oxygen-derived free radicals as regulators of toxicity in the benthic dinoflagellate Ostreopsis lenticularis. Proceedings of the Sixth International Conference on Toxic Marine Phytoplankton, Nantes, France, October, 1993.

Iglesias-Prieto R, Matta JL, Robins W, Trench RK. The effect of temperature on photosynthesis and respiration of the endosymbiotic dinoflagellate Symbiodinium microadriaticum (Freudenthal) to growth in vitro under varied oxygen tensions Proc Natl Acad Sci USA. Nov 1992;89(21):10302-10305.

Matta JL, Govind NS, Trench RK. Polyclonal antibodies against iron superoxide dismutases from E. coli B Cross-react with superoxide dismutases from the symbiotic dinoflagellate symbiodinium microadriaticum. J Phycol. Jun 1992;28(3):353-356.

Matta JL and Chapman DJ. Photosynthetic performance and daily carbon balance of Colpomenia peregrina: seasonal variations and differences between intertidal and subtidal populations. Mar Biol. 1991;108:303-313.

Matta JL and Trench RK. The Enzymatic response of the symbiotic dinoflagellate Symbiodinium microadriaticum (Freudenthal) to growth in vitro under varied oxygen tensions. Symbiosis. 1991;11:31-45.

5G12RR03050-19, Matta (PI)
0 9/01/2003-08/31/06
NIH/NCRR/RCMI

The focus of this study is to examine the hypothesis that a reduced DNA repair capacity (DRC) is a susceptibility factor for non-melanoma and melanoma skin cancers in Puerto Rico. In order to accomplish these general objectives, studies with the following specific aims are proposed: (1) Specific aim 1: Determine the DNA repair capacity of adults without skin cancer (controls) in Puerto Rican populations. (2) Specific aim 2: Determine the DNA repair capacity of non-melanoma (BCC and SCC) skin-cancer patients and compare them with controls. (3) Specific aim 3: Determine the DNA repair capacity of melanoma skin-cancer patients and compare them with controls.

S06 GM 08239-12, Matta (PI)
NIH-NIGMS/MBRS 05/01/97-04/30/01

Molecular mechanisms regulating the oxygen-activation/induction of manganese superoxide dismutase.

The goals of this research were to:

Test the hypothesis that oxygen induces the activity of MnSOD by increasing the synthesis of MnSOD protein and levels of translatable MnSOD mRNA.

Test the hypothesis that oxygen increases the transcription of the MnSOD gene.

NAG-2-1176, Matta (PI)
National Aeronautic Space Administration (NASA) 08/01/98-07/30/01

Mechanisms of UV-B induced free radical oxidative damage in bovine lenses and human fibroblasts

The goals of this research were:

To develop studies aimed at obtaining a better understanding of the mechanisms by which exposure to biological fluxes of UV-B can cause oxidative damage to bovine lenses, lens epithelial cells, and to human skin fibroblasts.

The second aim of this project was to provide rigorous research training to graduate and undergraduate students that have been traditionally under-represented in science and the NASA community.

NAG-2-1385, Matta (PI)
National Aeronautic Space Administration (NASA) 08/01/99-7/30/01

DNA repair and susceptibility to UV-induced basal cell carcinoma in Puerto Rican populations.

The goal of this research was: